These are the topics I plan to cover in the Genetics 2 section of my website. This list is not definite and will likely change. It is more of a guide to keep me on track.
RNA Molecules and RNA Processing
The Genetic Code and Translation
- Structure and Function of Proteins
- Degeneracy of the Genetic Code
- Reading Frame
- Initiation Codons
- Termination Codons
- Transfer RNA - Initiation of Translation
- Elongation
- Termination
- The Ribosome
- Polyribosomes
- mRNA - Post-translational Modifications of Proteins
Control of Gene Expression in Bacteria
- Levels of Gene regulation
- DNA Binding Proteins
- Operons
- Attenuation
- Antisense RNA - Riboswitches
- Ribozymes
Control of Gene Expression in Eukaryotes
- DNase 1
- Chromatin Remodeling
- Histone Modification
- DNA Methylation
- Transcriptional Activators, Repressors, and Coactivators
- Enhancers and Insulators
- RNA splicing
- Degradation of RNA - siRNA and microRNA
Gene Mutations and DNA Repair
- Importance of Mutations
- Types of Mutations
- Phenotypic Effects of Mutations
- Suppressor Mutations
- Mutation Rates
- Spontaneous Mutations
- Chemical Mutations
- Ames Test
- Transposition
- Mismatch Repair
- Direct Repair
- Base-Excision Repair
- Nucleotide-Excision Repair
Molecular Genetic Analysis and Biotechnology
- Cutting and Joining DNA fragements
- Southern Blotting
- Gene Cloning
- Pesticides
- PCR
- In Situ Hybridization
- Positional Cloning
- Gene Libraries
- DNA Sequencing
- DNA Finger Printing
- Restriction Fragment Length Polymorphisms
- Creating Random Mutations
- Mutagenesis
- Transgenic Animals
- Silencing Genes
- Knockout Mice
- Gene Therapy
Genomics and Proteomics
- Bioinformatics
- The Human Genome Project
- Single Nucleotide Polymorphisms
- Copy-Number Variations
- Reporter Sequences
- Genome-wide Mutagenesis
Epigenetics
- DNA Methylation
- Histone Modifications
- RNA molecules and Epigenetics
- Paramutation
- Chemicals and Epigenetics
- X Inactivation
- Epigenome
Developmental Genetics and Immunogenetics
- Egg-Polarity genes
- Segmentation Genes
- Organization of the Immune System
- the generation of Antibody Diversity
- Histocompatibility Complex Genes
- Tcell Receptor Diversity
- Genes and Organ Transplants
Cancer Genetics
- Tumor Formation
- Cancer as a Genetic Disease
- Environmental Factors and Cancer
- Oncogenes and Tumor Suppressor Genes
- Mutations in Cell Division Regulating Genes
- DNA Repair Genes
- Telomerase Regulating Genes
- Genes which Promote the Spread of Cancer
- MicroRNA and Cancer
- Epigenetics and Cancer
- Multiple mutations and Cancer
- Viruses and Cancer
Quantitative Genetics
- Genotype and Phenotype Relationship
- Polygenic Inheritance
- Quantitative Characteristics
- Distributions
- Samples and Populations
- Variance and Standard Deviation
- Correlation
- Regression
- Types of Heritability
- Limitations of Heritability
Population Genetics
- Genotypic Frequencies
- Allelic Frequencies
- Hardy-Weinberg Equilibrium
- Evolution and Population Genetics
- Mutation
- Migration
- Genetic Drift
- Natural Selection
Evolutionary Genetics
- Molecular Variation
- Protein Variation
- DNA sequence Variation
- The Biological Species Concept
- Reproductive Isolating Mechanisms
- Modes of Speciation
- Phylogenetic Trees
- The Molecular Clock
- Genome Evolution
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